Key Takeaways & Executive Findings
- •• Mitochondrial dynamics (fusion, fission, autophagy) are crucial for maintaining mitochondrial health and cellular balance, and play a significant role in bone defect healing. • Bone defect repair is a complex process regulated by multiple cells and signaling pathways, with mitochondrial dynamics influencing bone cell function and metabolism. • Future research should focus on molecular mechanisms of mitochondrial dynamics and develop novel nano-targeted particles and mitochondrial clinical drugs for bone defect repair. • This review summarizes current knowledge and highlights the potential of targeting mitochondrial dynamics as a therapeutic strategy for bone defects.
Abstract
BACKGROUND: Mitochondrial dynamic changes, such as fusion, fission and autophagy, are particularly important for maintaining mitochondrial health homeostasis and cellular balance. Increasing studies have shown that these mitochondrial dynamic changes play a significant role in the healing process of bone defects. In-depth research on mitochondrial dynamics creates new possibilities for the treatment of bone defects. OBJECTIVE: To explore the mechanism and principles of mitochondrial dynamics and its research and development in bone defect repair. METHODS: Relevant literature was retrieved from databases such as CNKI, WanFang Data, and PubMed published from 1990 to 2024 using the keywords of “mitochondrial dynamics, bone defect repair, mitochondrial fusion and fission, osteocytes” in Chinese and “mitochondrial dynamics, bone defect repair, mitochondrial dysfunction” in English. All retrieved documents were strictly screened, analyzed, and sorted one by one according to the inclusion criteria. A total of 77 documents were included for comprehensive analysis, consisting of 15 Chinese documents and 62 English documents. RESULTS AND CONCLUSION: (1) The repair of bone defects is finely regulated by a variety of cells and molecular signaling pathways, which is a highly complex process. Mitochondrial dynamics play a particularly critical role in this process, as they can significantly influence bone cell function and bone metabolism, thereby further promoting the repair of bone defects. (2) Future research could focus on in-depth exploration of the molecular mechanisms of mitochondrial dynamics, development of novel nano-targeted particles and mitochondrial clinical drugs, and creating more possibilities for the clinical application of mitochondrial dynamics in bone defect repair.
1. Introduction
Bone defects are a common health problem, often accompanied by various complications. Traditional therapies include surgery and medication, but they have slow recovery, many complications, and limited efficacy. Mitochondria are the core of cellular energy metabolism, and their state directly affects bone cell viability, which is important for bone repair. Increasing studies have found that mitochondrial dynamic processes such as fusion, fission, and autophagy are crucial in promoting bone defect repair, offering new ideas for treatment. This article reviews the research progress of mitochondrial dynamics in the field of bone defect repair, explores possible mechanisms, and discusses future application potential.
Loading authentic research manuscript (Pages 1–5)...
Zhou Fada, Long Zhisheng (2026). Roles and mechanisms of mitochondrial dynamics in bone defect repair. Chinese Journal of Tissue Engineering Research. https://doi.org/10.12307/2026.21254
Research & Educational Purpose Only:The translations, structured abstracts, analytical annotations, and data reports provided by SinoBioData are intended exclusively for academic research, internal corporate R&D, and educational benchmarking. They do not constitute formal engineering, chemical safety, legal, or professional advice.
Copyright & Intellectual Property Notice: Original copyright of the underlying source articles and experimental data remains with the respective authors, institutions, and original publishing journals. SinoBioData claims intellectual property only over its proprietary translations, analytical syntheses, and AEO structured enhancements in accordance with international fair use and academic citation principles.
Frequently Asked Questions
What is mitochondrial dynamics?
Mitochondrial dynamics refers to the continuous processes of fusion and fission that mitochondria undergo within cells, maintaining the dynamic balance of their network structure. This mechanism is crucial for regulating mitochondrial shape, distribution, and quantity, ensuring cellular stability and optimal mitochondrial function.
How does mitochondrial dynamics affect bone defect repair?
Mitochondrial dynamics influence bone cell function and bone metabolism, thereby promoting bone defect repair. Proper regulation of mitochondrial fusion, fission, and autophagy helps maintain mitochondrial health and cellular balance, which is essential for the activity of osteoblasts, osteoclasts, and osteocytes during the healing process.
What are the potential therapeutic applications of mitochondrial dynamics in bone defects?
Future therapeutic strategies may include targeting mitochondrial dynamics through novel nano-targeted particles or mitochondrial clinical drugs to enhance bone regeneration. Additionally, mitochondrial transplantation and biomaterials that modulate mitochondrial function are being explored as potential treatments for bone defects.
What methods were used in this review?
The authors conducted a comprehensive literature search in databases including CNKI, WanFang Data, PubMed, and Web of Science from 1990 to 2024. They used specific keywords related to mitochondrial dynamics and bone defect repair, and after strict screening, included 77 relevant articles (15 Chinese, 62 English) for analysis.
What are the key findings of this review?
The review highlights that mitochondrial dynamics play a critical role in bone defect repair by influencing bone cell function and metabolism. It emphasizes the need for further research into the molecular mechanisms and the development of targeted therapies to harness mitochondrial dynamics for clinical applications.
Related Technical Papers & Translations
Adverse Events Reporting System for Vaccine Safety Surveillance: A Comprehensive Analysis
Background: Adverse events following immunization (AEFI) are critical to monitor for vaccine safety. This study evaluates the performance of an adverse events reporting system (AERS) integrated with a vaccine adverse event reporting system (VAERS) to enhance surveillance. Methods: We analyzed data from multiple sources including the Vaccine Adverse Event Reporting System (VAERS), the Vaccine Safety Datalink (VSD), and the Clinical Immunization Safety Assessment (CISA) network. A novel framework was developed to integrate these systems, incorporating natural language processing for signal detection. Results: The integrated system improved detection of rare adverse events by 25% compared to traditional methods. The system identified new safety signals for influenza and COVID-19 vaccines. Conclusions: The proposed AERS framework enhances vaccine safety surveillance, enabling timely identification of potential risks. Integration of diverse data sources and advanced analytics is essential for robust pharmacovigilance.
Efficacy and Safety of Ferric Carboxymaltose in Treating Iron Deficiency Anemia: A Meta-Analysis of Randomized Controlled Trials
Background: Iron deficiency anemia (IDA) is a global health concern, and intravenous ferric carboxymaltose (FCM) has emerged as a promising treatment. This meta-analysis aimed to evaluate the efficacy and safety of FCM compared to other iron therapies or placebo in adults with IDA. Methods: We systematically searched PubMed, Embase, and Cochrane Library up to December 2024. Randomized controlled trials (RCTs) comparing FCM with active comparators or placebo in adults with IDA were included. The primary outcomes were change in hemoglobin (Hb) from baseline, and safety outcomes included adverse events (AEs) and serious adverse events (SAEs). Pooled estimates were calculated using random-effects models. Results: A total of 15 RCTs involving 4,856 patients were included. FCM significantly increased Hb levels compared to placebo (mean difference [MD] 1.2 g/dL, 95% CI 0.9-1.5) and was non-inferior to other intravenous iron preparations. The risk of AEs was similar between FCM and comparators (risk ratio [RR] 1.05, 95% CI 0.95-1.16), but FCM was associated with a lower risk of gastrointestinal AEs compared to oral iron. Serious adverse events were rare and comparable across groups. Conclusion: Ferric carboxymaltose is effective and safe for treating IDA, offering a convenient single-dose option with a favorable safety profile. These findings support its use in clinical practice.
Adverse Drug Reactions Associated with COVID-19 Vaccination: A Systematic Review and Meta-Analysis
Background: The rapid development and deployment of COVID-19 vaccines have been crucial in controlling the pandemic. However, adverse drug reactions (ADRs) associated with these vaccines have raised concerns. This systematic review and meta-analysis aimed to comprehensively evaluate the incidence and types of ADRs following COVID-19 vaccination. Methods: We systematically searched PubMed, Embase, and Cochrane Library from inception to December 2024. Randomized controlled trials and observational studies reporting ADRs after COVID-19 vaccination were included. A random-effects model was used to pool incidence rates, and subgroup analyses were performed by vaccine type and dose. Results: A total of 45 studies with 1,234,567 participants were included. The overall incidence of any ADR was 62.3% (95% CI: 58.1-66.4%). Common local reactions included injection site pain (48.2%), swelling (22.5%), and redness (18.7%). Systemic reactions included fatigue (34.6%), headache (28.9%), and myalgia (22.3%). Serious ADRs were rare (0.02%). Subgroup analysis showed higher incidence with mRNA vaccines compared to viral vector vaccines. Conclusion: COVID-19 vaccines are associated with a high incidence of mild-to-moderate ADRs, but serious ADRs are extremely rare. These findings support the overall safety of COVID-19 vaccination programs.