Key Takeaways & Executive Findings
- •• The field of brain organoid medical research has experienced rapid growth, with the United States leading in productivity and influence. • The University of California system is the top contributing institution, and extensive collaborative networks exist among institutions, though inter-team collaboration remains limited. • Long-term research hotspots include pluripotent stem cells, in vitro models, and culture, while recent focus has shifted to choroid plexus, human cortical organoids, and microglia. • Future directions emphasize interdisciplinary integration of brain organoid culture with bioengineering technologies to enhance model maturity for regenerative medicine and brain disease research.
Abstract
BACKGROUND: In recent years, brain organoids have rapidly emerged as a hotspot in neuroscience research; however, no comprehensive analysis of knowledge graphs related to medical research on brain organoid has been conducted. OBJECTIVE: To conduct a bibliometric analysis of brain organoid medical research and systematically collate research hotspots, emerging trends, and developmental trajectories in this field, thereby providing scholars with a rapid and systematic overview of the current landscape. METHODS: Relevant publications on brain organoids from January 1, 2014 to December 31, 2024 were retrieved and analyzed using the Web of Science Core Collection. CiteSpace, Microsoft Office, and Origin software were used to systematically analyze publication volume, country distribution, institutional contributions, authors, highly cited references, and keyword hotspots. RESULTS AND CONCLUSION: The number of publications in the field of brain organoid medical research has shown a continuous rapid growth trend, with the United States leading in publication volume and influence. The University of California system is the highest-producing institution, and most institutions have frequent cooperation and exchange, forming a broad cooperation network. Research teams are closely connected internally, but cooperation between teams is limited. The most prolific author is Knoblich J. After 2021, research hotspots entered a period of concentrated outbreak. Long-term research hotspots include pluripotent stem cells, in vitro models, and culture. Recent hotspot research directions include choroid plexus, human cortical organoids, and microglia. The results indicate that the field of brain organoid medical research has entered a new stage of rapid development in recent years, with high thematic diversity. In vitro three-dimensional model culture has always been a research hotspot. Future research will focus on interdisciplinary integration of brain organoid culture and bioengineering technology to optimize model maturity, providing a precise in vitro research platform for regenerative medicine, brain disease treatment, and exploration of neurological mechanisms.
1. Introduction
The human brain is the most complex system known among all organisms, with over 60 trillion neuronal connections in the adult brain [1]. Brain organoids can simulate the complex structure and function of the human brain, providing a new platform for research in regenerative medicine, disease modeling, and drug screening [2-3]. Since the first report on brain organoid technology in September 2013 [4], it has rapidly become a hotspot in neuroscience research; however, no comprehensive analysis of knowledge graphs related to medical research on brain organoids has been conducted.
Bibliometrics, through visual display and systematic analysis, can clearly and intuitively present specific information on countries, institutions, journals, authors, keywords, and references [5], revealing the development trends and hotspots in a research field [6]. This study retrieved articles related to brain organoids from the Web of Science Core Collection database over the past 10 years and conducted a bibliometric analysis to systematically summarize the research hotspots, latest developments, and trends in the field of brain organoid medicine, providing scholars with a rapid and systematic overview of the field [7].
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HE Ren-da, MA Wei, SUN Yong-si, MO Xue-ni (2026). Future medical research on brain organoids: interdisciplinary training, bioengineering technologies, and optimized model maturity. Chinese Journal of Tissue Engineering Research. https://doi.org/10.12307/2026.21506
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Frequently Asked Questions
What is the current state of research on brain organoids?
Research on brain organoids has grown rapidly since 2013, with the United States leading in publication output and influence. The field is characterized by high thematic diversity, with long-term hotspots including pluripotent stem cells, in vitro models, and culture, and recent focus on choroid plexus, human cortical organoids, and microglia.
What are the main research hotspots in brain organoid medical research?
Long-term hotspots include pluripotent stem cells, in vitro models, and culture. Recent hotspots have shifted to choroid plexus, human cortical organoids, and microglia, indicating a trend towards more complex and disease-relevant models.
What are the future directions for brain organoid research?
Future research will focus on interdisciplinary integration of brain organoid culture with bioengineering technologies to optimize model maturity, aiming to provide precise in vitro platforms for regenerative medicine, brain disease treatment, and neurological mechanism exploration.
Which institutions and authors are leading in brain organoid research?
The University of California system is the highest-producing institution, and the most prolific author is Knoblich J. Extensive collaborative networks exist among institutions, though inter-team collaboration is limited.
What methods were used in this bibliometric analysis?
The study retrieved publications from the Web of Science Core Collection (2014-2024) and used CiteSpace, Microsoft Office, and Origin software to analyze publication volume, country distribution, institutional contributions, authors, highly cited references, and keyword hotspots.
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