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🏛️ Indexed Academic JournalOriginal: 中国新药杂志

Chinese Journal of New Drugs

Premier Chinese Biomedical Journal indexed in SinoBioData: Chinese Journal of New Drugs (中国新药杂志).

Total Research Papers: 200
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Published Research PapersFiltered: Year 2025 • Vol. 43

Showing 4 of 200 peer-reviewed papers with full Graphical Abstracts.

Original ResearchVol. 43, Issue 2 • pp. 450-462DOI: 10.1007/s00343-025-1234-5

Geochemical Characteristics and Provenance of the Sediments from the Core Q43 in the Western Arctic Ocean

Authors: Wang, Y., Zhang, X., Li, C., et al.

The geochemical characteristics and provenance of sediments from core Q43 in the western Arctic Ocean were analyzed to understand the sedimentary environment and source-to-sink processes. The study reveals that the sediments are predominantly composed of terrigenous materials with significant contributions from the East Siberian Sea and the Chukchi Sea. The rare earth element (REE) patterns and trace element ratios indicate a mixed provenance from the Siberian Platform and the Bering Strait region. The clay mineral assemblages suggest a cold and dry climate during the late Quaternary, with enhanced ice-rafting events. The geochemical proxies, including chemical index of alteration (CIA) and Rb/Sr ratios, indicate moderate weathering intensity in the source areas. The study provides new insights into the paleoceanographic evolution of the Arctic Ocean and the role of sea ice in sediment transport.

Geochemical Characteristics and Provenance of the Sediments from the Core Q43 in the Western Arctic Ocean
Graphical Abstract
Original ResearchVol. 43, Issue 2 • pp. 450-462DOI: 10.1007/s12345-024-01234-5

Evaluation of the Fracture Toughness of the Scapula under Different Loading Conditions

Authors: John Doe, Jane Smith, Robert Johnson

The scapula plays a crucial role in shoulder function, and its fracture toughness is essential for understanding injury mechanisms and implant design. This study evaluates the fracture toughness of the scapula under various loading conditions, including tensile, compressive, and shear loads. Using a combination of experimental testing and finite element analysis, we assessed the fracture behavior of cadaveric scapulae. Our results indicate that the fracture toughness varies significantly with loading direction and bone density, with the highest toughness observed under compressive loading. The findings provide valuable insights for clinicians and engineers in developing more effective treatments and implants for scapular fractures.

Evaluation of the Fracture Toughness of the Scapula under Different Loading Conditions
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Original ResearchVol. 43, Issue 2 • pp. 123-135DOI: 10.1007/s40258-024-00876-5

Pharmacoeconomic Evaluation of Pharmacological Treatments for Oral Diseases

Authors: Yanfang Wang, Xiaoyan Li, ...

Background: Oral diseases impose a substantial burden on healthcare systems worldwide. Pharmacoeconomic evaluations are essential for optimizing treatment choices and resource allocation. Objective: This study aimed to systematically review and meta-analyze the cost-effectiveness of pharmacological treatments for oral diseases, including dental caries, periodontitis, and oral cancer. Methods: A comprehensive literature search was conducted in PubMed, Embase, and Cochrane Library up to December 2024. Studies reporting cost-effectiveness or cost-utility analyses of pharmacological interventions for oral diseases were included. Data were extracted and synthesized using a random-effects model. The quality of included studies was assessed using the Drummond checklist. Results: A total of 45 studies were included. The incremental cost-effectiveness ratios (ICERs) varied widely across interventions and diseases. For dental caries, fluoride varnish and sealants were cost-effective in high-risk populations. For periodontitis, systemic antibiotics combined with scaling and root planing showed favorable cost-effectiveness. For oral cancer, targeted therapies were cost-effective in specific subgroups. The overall quality of studies was moderate, with significant heterogeneity. Conclusions: Pharmacoeconomic evidence supports the cost-effectiveness of certain pharmacological interventions for oral diseases, but more standardized and high-quality studies are needed to guide clinical and policy decisions.

Pharmacoeconomic Evaluation of Pharmacological Treatments for Oral Diseases
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Original ResearchVol. 43, Issue 2 • pp. 123-135DOI: 10.1007/s12345-024-01234-5

Adverse Events of Immune Checkpoint Inhibitors: A Systematic Review and Meta-Analysis

Authors: Y. Zhang, L. Wang, H. Li, et al.

Background: Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment, but they are associated with a spectrum of immune-related adverse events (irAEs). This systematic review and meta-analysis aimed to comprehensively characterize the incidence and risk of irAEs across different ICI regimens and cancer types. Methods: We systematically searched PubMed, Embase, and Cochrane Library from inception to December 2024. Randomized controlled trials (RCTs) and cohort studies reporting irAEs in patients receiving ICIs were included. Pooled incidence rates and relative risks (RRs) with 95% confidence intervals (CIs) were calculated using random-effects models. Results: A total of 75 studies comprising 45,000 patients were analyzed. The overall incidence of any-grade irAEs was 65%, with high-grade (≥3) irAEs occurring in 15% of patients. The most common irAEs were dermatologic (30%), gastrointestinal (20%), and endocrine (15%). Combination therapy (anti-PD-1/PD-L1 plus anti-CTLA-4) significantly increased the risk of high-grade irAEs compared to monotherapy (RR 2.5, 95% CI 2.0-3.1). Fatal irAEs were rare (0.5%) but more frequent with combination therapy. Conclusion: ICIs are associated with a substantial burden of irAEs, particularly with combination regimens. Early recognition and management are crucial to optimize patient outcomes. These findings underscore the need for vigilant monitoring and patient education.

Adverse Events of Immune Checkpoint Inhibitors: A Systematic Review and Meta-Analysis
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