Drug Repurposing for Cancer Therapy: A Systematic Review of Non-Oncology Drugs with Anticancer Properties
Authors: Y. Zhang, L. Wang, H. Chen, et al.
Drug repurposing offers a promising strategy to accelerate cancer therapy development by identifying new anticancer indications for existing non-oncology drugs. This systematic review evaluates the current landscape of drug repurposing in oncology, focusing on the mechanisms, clinical evidence, and challenges. We analyzed 150 studies and identified 45 non-oncology drugs with significant preclinical and clinical anticancer activity. Key findings include the role of drug repurposing in overcoming drug resistance, reducing costs, and shortening development timelines. However, challenges such as regulatory hurdles, patent issues, and the need for robust biomarkers remain. Our review highlights the potential of drug repurposing as a viable approach for cancer treatment and provides a framework for future research.
