Zinc fingers are responsible for the efficient control of KLF7 on the transcription of genes in the NF-κB signaling pathway and fatty acid β-oxidation

• KLF7 zinc fingers are essential for its regulatory control over NF-κB signaling and fatty acid β-oxidation genes. • Deletion of zinc fingers alters NF-κB pathway activity in a cell-type-specific manner, with loss reducing activity in HeLa and EC109 cells but increasing it in Ishikawa cells. • The ability of KLF7 to upregulate proinflammatory cytokines IL-6 and TNF-α is diminished upon zinc finger loss. • These findings highlight the potential of targeting KLF7 zinc fingers for therapeutic intervention in inflammatory and metabolic diseases.