• miR-155 is overexpressed in glioma and directly targets JARID2, inhibiting its expression and promoting tumor cell viability while suppressing apoptosis.
• Knockdown of JARID2 partially reverses the tumor-suppressive effects of miR-155 inhibition, confirming the functional relevance of the miR-155/JARID2 axis in glioma.
• Valproic acid (VPA) upregulates JARID2 expression by increasing methylation of the miR-155 promoter, thereby downregulating miR-155 and inhibiting glioma cell growth.
• The study identifies a novel epigenetic mechanism for VPA's anti-glioma activity, offering a potential therapeutic strategy targeting the miR-155/JARID2 axis.