Types of cell death in diabetic cardiomyopathy: insights from animal models

• Diabetic cardiomyopathy (DCM) is a major complication of diabetes, affecting ~26% of patients, and is a leading cause of heart failure. • Regulated cell death pathways—apoptosis, necroptosis, ferroptosis, and cuproptosis—are implicated in DCM pathogenesis. • Animal models are crucial for studying DCM; this review evaluates their suitability and the roles of these cell death types. • Targeting these cell death pathways may offer novel therapeutic strategies to limit DCM progression.