• Combination therapy of En-PSCs and HSYA significantly improves uterine repair in rats with full-thickness injury, reducing fibrosis and enhancing regeneration.
• The treatment promotes angiogenesis and restores fertility, leading to increased live births in the rat model.
• Mechanistically, En-PSCs/HSYA activates the NRG1/ErbB4 signaling pathway, which is crucial for the therapeutic effects.
• This study provides a promising cell-based therapeutic strategy for intrauterine adhesions, potentially applicable to clinical settings.