Therapeutic potential of targeting the NEDD4L-eEF1A1 axis in cancer therapy

• NEDD4L overexpression in HUVECs suppresses proliferation and migration, while enhancing autophagy. • NEDD4L promotes K48-linked ubiquitination and degradation of eEF1A1, a key mechanism in regulating endothelial cell function. • Loss of endothelial NEDD4L enhances tumor growth and angiogenesis in vivo, underscoring its tumor-suppressive role. • The NEDD4L-eEF1A1 axis represents a novel therapeutic target for cancer therapy by inhibiting angiogenesis.