The therapeutic efficacy comparison of MSCs derived different tissues unveilings anti-apoptosis more crucial than angiogenesis in treating acute myocardial infarction

• UCMSCs exhibit superior pro-angiogenic activity compared to ADMSCs in vitro and in vivo. • ADMSCs provide better cardioprotection than UCMSCs in a mouse MI model, primarily through stronger anti-apoptotic effects. • Anti-apoptosis is more crucial than angiogenesis for MSC-based therapy in acute myocardial infarction. • The study highlights the importance of MSC source selection for precision medicine in cardiac repair.