The local pulsatile parathyroid hormone delivery system induces the osteogenic differentiation of dental pulp mesenchymal stem cells to reconstruct mandibular defects

• A local pulsatile PTH delivery system enhances osteogenic differentiation of DPSCs, promoting mandibular bone regeneration. • The system shows excellent biocompatibility with DPSCs, supporting cell adhesion and viability. • In vivo studies confirm effective repair of critical-sized mandibular defects in a rabbit model. • This approach offers a promising strategy for reconstructing large mandibular defects, addressing limitations of current grafting methods.