The interaction and balance between cellular senescence and tissue repair

• Cellular senescence plays a dual role in tissue repair, with both beneficial and detrimental effects depending on context. • Senescent cells accumulate with age and secrete SASP factors that contribute to chronic inflammation and impaired tissue regeneration. • Targeted clearance of senescent cells using senolytics, gene editing, or immunotherapy shows promise in alleviating aging-related diseases and promoting tissue repair. • Non-targeted interventions such as lifestyle changes can also modulate senescence and improve healthspan.