• Norepinephrine (NE) induces ovarian dysfunction in mice by triggering ferroptosis, evidenced by disrupted estrous cycles, altered hormone levels, and reduced follicle counts.
• RNA sequencing reveals significant enrichment of ferroptosis-related genes in NE-treated ovarian tissues, with increased ROS, ferrous ions, and MDA, and decreased GPX4 expression.
• Coenzyme Q10 (CoQ10) reverses NE-induced ferroptosis in vitro and in vivo, restoring GPX4 levels and reducing oxidative stress markers.
• CoQ10 supplementation improves ovarian function in NE-treated mice, suggesting a potential therapeutic strategy for stress-related ovarian dysfunction.