Official PDF Translation•Acta Biochimica et Biophysica Sinica

The E2F1-KIF14 axis drives focal adhesion formation and promotes colorectal cancer metastasis

Authors: Yajie Wang; Xinyue Wu; Xiaofeng Li; Xiaoying Lian; Jiao An; Wenhua Cai; Jing Jia; Changjun Zhu

DOI: 10.3724/abbs.2025158Status: Verified Translated Edition

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Key Findings in This Report

• KIF14 is upregulated in colorectal cancer and correlates with advanced tumor stage and poor overall survival. • KIF14 promotes CRC metastasis by regulating focal adhesion dynamics and cell-matrix adhesion signaling. • Mechanistically, KIF14 binds to vinculin and facilitates its delivery to the leading edge, while E2F1 transcriptionally activates KIF14. • The E2F1-KIF14-vinculin axis represents a novel therapeutic target for metastatic colorectal cancer.