• T cell-intrinsic PRR signaling directly modulates T cell function, challenging the traditional innate-adaptive immunity dichotomy.
• PRRs integrate danger signals and microbial cues to regulate cytokine production, proliferation, and polarization, impacting disease outcomes.
• Dysregulated PRR signaling in T cells contributes to autoimmune diseases, chronic infections, and cancer, revealing dual roles in immunity.
• Understanding PRR-mediated T cell regulation offers novel therapeutic targets for inflammatory and neoplastic diseases.