Official PDF Translation•Acta Biochimica et Biophysica Sinica

SPATS2L is a positive feedback regulator of the type I interferon signaling pathway and plays a vital role in lupus

Authors: Mengke Chen; Yutong Zhang; Weiwen Shi; Xuejiao Song; Yue Yang; Guojun Hou; Huihua Ding; Sheng Chen; Wanling Yang; Nan Shen; Yong Cui; Xianbo Zuo; Yuanjia Tang

DOI: 10.3724/abbs.2024132Status: Verified Translated Edition

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Key Findings in This Report

• SPATS2L is identified as an SLE eGene correlated with disease activity and involved in the type I IFN pathway. • SPATS2L expression is induced by type I IFN in a dose- and time-dependent manner, acting as a positive feedback regulator. • Silencing SPATS2L in PBMCs from SLE patients reverses IFN pathway activation, highlighting its therapeutic potential. • SPATS2L may serve as a biomarker for disease activity and a target for intervention in lupus.