• Plasma sPRR levels are significantly elevated in patients with atherosclerosis compared to non-AS controls, suggesting its potential as a novel laboratory biomarker.
• In a mouse model of atherosclerosis (ApoE–/– mice fed a high-fat diet), plasma sPRR levels were also significantly increased, corroborating the clinical findings.
• The study provides evidence that sPRR may serve as a non-invasive indicator for atherosclerosis severity, potentially aiding in early diagnosis and risk stratification.
• These findings highlight the role of the (pro)renin receptor in atherosclerosis pathophysiology and open avenues for targeted therapeutic strategies.