Official PDF Translation•Acta Biochimica et Biophysica Sinica

Silencing of PCK1 mitigates the proliferation and migration of vascular smooth muscle cells and vascular intimal hyperplasia by suppressing STAT3/DRP1-mediated mitochondrial fission

Authors: Li Zhang; Yingmei Chen; Quanrong Pan; Shizheng Fang; Zhongjian Zhang; Jia Wang; Yongjian Yang; Dachun Yang; Xiongshan Sun

DOI: 10.3724/abbs.2024154Status: Verified Translated Edition

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Key Findings in This Report

• PCK1 expression is upregulated in injured arteries and contributes to neointimal hyperplasia and restenosis. • Silencing PCK1 inhibits VSMC proliferation and migration by reducing DRP1-mediated mitochondrial fission. • The STAT3/DRP1 axis is a critical downstream pathway mediating the effects of PCK1 on VSMC function. • Targeting PCK1 may offer a novel therapeutic strategy for preventing vascular restenosis after angioplasty.