Official PDF Translation•Stem Cell Research & Therapy

Research based on serine metabolism indicates mesenchymal stem cells alleviate psoriasis by regulating the PSPH-PINK1-Parkin-NLRP3 pathway in HaCaT

Authors: Qing Lin; Yunfei Ji; Bin Yang; Rongjia Zhu; Ping Song; Robert Chunhua Zhao

DOI: 10.1186/s13287-026-04964-zStatus: Verified Translated Edition

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Key Findings in This Report

• MSCs alleviate IMQ-induced psoriasis in mice by upregulating serine metabolism and enhancing PSPH expression. • MSCs activate the PINK1-Parkin mitophagy pathway in psoriatic HaCaT cells, leading to reduced NLRP3 inflammasome activation and decreased inflammatory cytokines. • Knockdown of PSPH reverses the therapeutic effects of MSCs, confirming its critical role in mediating the anti-inflammatory action. • MSCs restore skin barrier function by increasing claudin-1 expression and normalizing keratinocyte differentiation markers KRT1 and KRT6.