• The mZIF-8/PLA membrane, fabricated via electrospinning and biomimetic mineralization, exhibits enhanced hydrophilicity and cell compatibility, promoting osteogenesis and angiogenesis in BMSCs.
• The membrane induces M2 macrophage polarization, modulating the local immune microenvironment to support bone regeneration.
• In vivo, the membrane bridges critical-sized bone defects within 4 weeks and achieves near-complete repair by 12 weeks, with improved bone strength and vascularization.
• This dual-functional membrane offers a promising strategy for guided bone regeneration, addressing limitations of current barrier membranes in osteoinduction and immunomodulation.