• Optimized extraction conditions for dihydromyricetin from vine tea using response surface methodology, achieving a yield of 12.35 mg/g.
• Identified key process parameters (temperature, time, liquid-to-solid ratio, ethanol concentration) significantly affecting extraction efficiency.
• Network pharmacology analysis revealed that DHM may target multiple proteins and pathways involved in liver fibrosis, including PI3K-Akt and MAPK signaling.
• Provides a foundation for industrial-scale extraction and therapeutic application of DHM in liver fibrosis treatment.