NQO1 promotes osteogenesis and suppresses angiogenesis in DPSCs via MAPK pathway modulation

• NQO1 suppresses angiogenesis in dental pulp stem cells (DPSCs) both in vitro and in vivo, as evidenced by reduced tubule formation and CD31 expression. • NQO1 enhances osteogenesis of DPSCs, indicated by increased ALP activity, alizarin red staining, and DSPP expression. • The effects of NQO1 are mediated through downregulation of MAPK signaling and enhancement of mitochondrial respiration, with CoQ10 reversing these effects. • These findings suggest NQO1 as a potential therapeutic target for arteriosclerosis by promoting vascular repair and inhibiting calcification.