Morphometric prediction of mesenchymal stromal cell-like immunosuppressive capacity of human hair follicle dermal sheath cup cells: an implication for regenerative medicine in hair loss diseases

• DSCCs exhibit MSC-like immunosuppressive capacity, reducing T cell proliferation from 78% to 5% in co-culture. • A novel in vitro morphometric assay predicts DSCC immunosuppressive potential, enabling quality control for regenerative medicine. • DSCCs show low immunogenicity and multipotency, supporting their use in allogeneic and autologous cell therapies. • The predictive model facilitates donor and manufacturing condition selection for consistent therapeutic efficacy in hair loss treatment.