Official PDF Translation•Stem Cell Research & Therapy

Melatonin-pretreated mesenchymal stem cell-derived exosomes alleviate cavernous fibrosis in a rat model of nerve injury-induced erectile dysfunction via miR-145-5p/TGF-β/Smad axis

Authors: Xiaolin Zhang; Mengbo Yang; Xinda Chen; Ming Zhang; Yiliang Peng; Mujun Lu

DOI: 10.1186/s13287-025-04173-0Status: Verified Translated Edition

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Key Findings in This Report

• MT-hASC-EVs significantly restore erectile function and reduce cavernous fibrosis in a rat model of CNI-ED. • Mechanistically, MT-hASC-EVs deliver miR-145-5p to target the TGF-β2/Smad3 axis, inhibiting fibrosis. • MT-hASC-EVs promote proliferation and anti-apoptosis of corpus cavernosum smooth muscle cells in vitro. • This study suggests a novel cell-free therapeutic strategy for CNI-ED using melatonin-pretreated stem cell exosomes.