Official PDF Translation•Chinese Journal of Pathophysiology

Melatonin alleviated acute myocardial infarction by inhibiting ferroptosis

Authors: HUANG Xiaohui; WEN Weixing; CHEN Peng; LI Weiwen; LI Jiahuan; CAO Yue; HU Yunzhao; HUANG Yuli

DOI: 10.3969/j.issn.1000-4718.2025.09.002Status: Verified Translated Edition

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Key Findings in This Report

• Melatonin reduces oxidative stress and lipid peroxidation in hypoxic cardiomyocytes, inhibiting ferroptosis. • Melatonin improves myocardial infarction size, cardiac injury, and pathological changes in a rat model of AMI. • The cardioprotective effect of melatonin is linked to suppression of iron accumulation and ferroptosis. • Targeting ferroptosis with melatonin may offer a novel therapeutic strategy for acute myocardial infarction.