• Epothilone B significantly improves motor function recovery in rats after spinal cord injury, as evidenced by increased BBB scores, inclined plane test angles, and open field test distances.
• Epothilone B enhances blood flow recovery and reduces spinal cord cavity area, indicating improved microcirculation and tissue preservation.
• Epothilone B downregulates Toll-like receptor 4 and nuclear factor κB protein expression, suggesting attenuation of the inflammatory response.
• Epothilone B upregulates vascular endothelial growth factor receptor 2 expression, promoting vascular endothelial cell regeneration and microcirculation reconstruction.