Official PDF Translation•Acta Biochimica et Biophysica Sinica

lncRNA CYTOR promotes lung adenocarcinoma gemcitabine resistance and epithelial-mesenchymal transition by sponging miR-125a-5p and upregulating ANLN and RRM2

Authors: Qijun Cao; Haixia Wang; Jialong Zhu; Chen Qi; Hairong Huang; Xiaoyuan Chu

DOI: 10.3724/abbs.2023287Status: Verified Translated Edition

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Key Findings in This Report

• CYTOR is significantly upregulated in LUAD and serves as an independent poor prognostic biomarker. • CYTOR promotes gemcitabine resistance and epithelial-mesenchymal transition (EMT) in LUAD cells. • Mechanistically, CYTOR acts as a ceRNA by sponging miR-125a-5p, leading to upregulation of ANLN and RRM2. • This study provides a novel therapeutic target and theoretical basis for overcoming chemoresistance in LUAD.