• iPSC-derived exosomes significantly accelerate diabetic wound healing in two clinically relevant animal models.
• The therapeutic mechanism involves direct activation of tissue regeneration, including re-epithelialization and remodeling.
• iPSC-Exos modulate the inflammatory microenvironment by promoting macrophage polarization toward the anti-inflammatory M2 phenotype.
• The dual-animal model approach enhances clinical translatability of findings for diabetic wound therapy.