Official PDF Translation•Chinese Journal of Tissue Engineering Research

Intervention Effect and Mechanism of Compound Herba Gueldenstaedtiae in a Mouse Model of Breast Hyperplasia

Authors: Wu Yilin; Tian Hongying; Sun Jiale; Jiao Jiajia; Zhao Zihan; Shao Jinhuan; Zhao Kaiyue; Zhou Min; Li Qian; Li Zexin; Yue Changwu

DOI: 10.12307/2026.21150Status: Verified Translated Edition

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Key Findings in This Report

• Compound Herba Gueldenstaedtiae and its probiotic fermentation products significantly improved mammary gland hyperplasia in mice. • Network pharmacology identified 50 potential targets of the compound related to breast hyperplasia. • The treatment regulated hormone levels, improved gut microbiota structure, and increased short-chain fatty acid content. • The compound and its fermented products may serve as potential therapeutic agents for breast hyperplasia.