Official PDF Translation•Acta Biochimica et Biophysica Sinica

Integrins and NAFLD-associated liver diseases: clinical associations, pathophysiological mechanisms and pharmacological implications

Authors: Yangyue Ni; Mengwen Huang; Shiyang Chen; Shihui Wang; Jianfeng Chen

DOI: 10.3724/abbs.2024149Status: Verified Translated Edition

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Key Findings in This Report

• Integrins are key regulators in NAFLD progression, influencing steatosis, HSC activation, and immune infiltration. • The review highlights integrin-mediated signaling pathways as potential therapeutic targets for NAFLD and NASH. • Current clinical and preclinical integrin-targeting drugs show promise for treating steatosis, inflammation, fibrosis, and NAFLD-related HCC. • Understanding integrin functions may lead to novel diagnostic and treatment strategies for NAFLD-associated liver diseases.