Inducible Fgf13 ablation alleviates cardiac fibrosis via regulation of microtubule stability

• Inducible Fgf13 ablation attenuates cardiac fibrosis and improves cardiac function in a mouse model of pressure overload. • FGF13 promotes cardiac fibroblast activation, proliferation, and migration in response to TGFβ stimulation. • The pro-fibrotic effect of FGF13 depends on its microtubule-binding and stabilizing function. • FGF13 regulates the ROCK signaling pathway via microtubule stability, offering a potential therapeutic target for cardiac fibrosis.