Official PDF Translation•Stem Cell Research & Therapy

Improvement of multilineage hematopoiesis in hematopoietic stem cell-transferred c-kit mutant NOG-EXL humanized mice

Authors: Ryoji Ito; Yusuke Ohno; Yunmei Mu; Yuyo Ka; Shuko Ito; Maiko Emi-Sugie; Misa Mochizuki; Kenji Kawai; Motohito Goto; Tomoyuki Ogura; Riichi Takahashi; Akira Niwa; Tatsutoshi Nakahata; Mamoru Ito

DOI: 10.1186/s13287-024-03799-wStatus: Verified Translated Edition

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Key Findings in This Report

• NOGW mice with c-kit mutation enable efficient human hematopoietic engraftment with reduced CD34+ cell numbers and without irradiation. • NOGW-EXL mice support enhanced multilineage reconstitution, particularly granulocytes and platelets/megakaryocytes, in non-irradiated recipients. • NOGW mice demonstrate superior long-term hematopoietic stem cell potential in serial transplantation assays. • The NOGW-EXL humanized mouse model offers a versatile platform for studying human hematology and immunology with broader accessibility.