Importance of PTM of FLT3 in acute myeloid leukemia

• Glycosylation of FLT3 determines its subcellular localization and downstream signaling activation, with implications for AML pathogenesis. • Ubiquitination regulates FLT3 stability and function, and its dysregulation may contribute to disease progression. • Combining FLT3 tyrosine kinase inhibitors with drugs targeting glycosylation or ubiquitination represents a promising therapeutic strategy. • Understanding PTMs of FLT3 is crucial for developing targeted therapies in AML, especially for mutant forms.