Official PDF Translation•Acta Biochimica et Biophysica Sinica

IKZF3 promotes gastric cancer progression via Hedgehog signaling activation and is targetable by SANT-1

Authors: Muhammad Ali; Shantanu Baral; Jun Ren; Liuhua Wang; Bin Liu; Sen Wang; Daorong Wang

DOI: 10.3724/abbs.2025103Status: Verified Translated Edition

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Key Findings in This Report

• IKZF3 is overexpressed in gastric cancer tissues and promotes cancer cell proliferation, migration, and invasion. • IKZF3 activates the Hedgehog signaling pathway by binding to the SMO promoter and upregulating SMO expression. • Knockdown of IKZF3 induces G1/S cell cycle arrest, and the SMO inhibitor SANT-1 reverses IKZF3-mediated oncogenic effects. • Targeting IKZF3 with SANT-1 represents a promising therapeutic strategy for gastric cancer treatment.