Official PDF Translation•Acta Biochimica et Biophysica Sinica

Identification of RACK1 as a novel regulator of non-structural protein 4 of chikungunya virus

Authors: Yao Yan; Fengyuan Zhang; Meng Zou; Hongyu Chen; Jingwen Xu; Shuaiyao Lu; Hongqi Liu

DOI: 10.3724/abbs.2024073Status: Verified Translated Edition

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Key Findings in This Report

• RACK1 is identified as a novel host interactor of CHIKV nsP4, regulating its stability via the ubiquitin-proteasome pathway. • Harringtonolide disrupts RACK1-nsP4 interaction, promoting nsP4 degradation and reducing viral replication potential. • Proteasome inhibitor MG132 reverses RACK1 inhibitor-induced nsP4 degradation, confirming proteasomal involvement. • Targeting RACK1-nsP4 interaction offers a promising therapeutic strategy against chikungunya virus.