• hPD-MSCs exhibit classical MSC features including surface markers (CD90, CD73, CD105, CD44, CD106) and differentiation into adipogenic and osteogenic lineages.
• Transcriptomic analysis reveals that hPD-MSCs share significant gene expression similarities with pancreatic stellate cells (PSCs), suggesting a potential lineage relationship.
• Specific genes (ISL1, NPTX1, ZNF804A) distinguish hPD-MSCs from MSCs of other origins, implicating roles in pancreatic function and neural development.
• A novel gene (ENSG00000286190) with unknown function was identified, offering a new avenue for research in pancreatic MSC biology.