Official PDF Translation•Acta Biochimica et Biophysica Sinica

HDAC11 in ovarian granulosa cells coordinates LH in the maturation of oocytes in Tan sheep

Authors: Jiaqi Shi; Donghuan Lv; Yaxiu Xu; Xiangyan Wang; Zhipeng Qi; Yujie Yan; Jinghua Wang; Hongyuan Song; Hui Yang; Luguo Jin; Zhengyi Yang; Xiaoning Yang; Xiumei Kang; Xinfeng Liu; Zhuming Zhang; Chao Wang

DOI: 10.3724/abbs.2025036Status: Verified Translated Edition

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Key Findings in This Report

• HDAC11 expression in ovarian granulosa cells and oocytes of Tan sheep increases with follicular growth and maturation. • Pharmacological inhibition of HDAC11 by SIS17 reduces oocyte maturation rate under LH supplementation in vitro. • HDAC11 inhibition elevates H3K9 acetylation and decreases AREG levels, while reducing YAP1, a negative regulator of AREG. • HDAC11 in granulosa cells promotes LH-induced AREG production during oocyte in vitro maturation by modulating H3K9ac and YAP1.