Official PDF Translation•Stem Cell Research & Therapy

From inflammation to healing: the crucial role of GPR91 activation and SDH inhibition in chronic diabetic wound recovery

Authors: Hengdeng Liu; Shixin Zhao; Hanwen Wang; Xuefeng He; Suyue Gao; Minmin Su; Miao Zhen; Shuying Chen; Lei Chen; Julin Xie

DOI: 10.1186/s13287-025-04480-6Status: Verified Translated Edition

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Key Findings in This Report

• GPR91 activation and SDH inhibition synergistically improve high glucose-induced M2 macrophage dysfunction, reducing inflammation and promoting diabetic wound healing. • GPR91 overexpression enhances anti-inflammatory responses and preserves epidermal stem cell stemness via HGF-mediated signaling. • SDH inhibition with dimethyl malonate reduces ROS and upregulates GPR91, activating the PI3K-Akt/pERK1/2 pathway to boost M2 macrophage function. • Dual targeting of GPR91 and SDH offers a novel therapeutic strategy for chronic diabetic foot ulcers.