Official PDF Translation•Acta Biochimica et Biophysica Sinica

FGF10 is essential for postnatal meibomian gland development in mice

Authors: Zelong Jiang; Lue Xiang; Yubin Yu; Qiqi Wu; Shuangyan Peng; Yang Yu; Fangyi Lv; Zi Jin; Deyin He; Juan Li; Xiaokun Li; Xiaojie Wang; Fengqin Rao

DOI: 10.3724/abbs.2026066Status: Verified Translated Edition

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Key Findings in This Report

• FGF10 haploinsufficiency causes severe meibomian gland atrophy and impaired tear production in mice. • FGF10 deficiency leads to dysregulation of immune-related pathways, particularly macrophage and dendritic cell functions. • CX3CR1-positive immune cells are reduced in Fgf10+/− meibomian glands, suggesting a role in gland development. • Pharmacological ablation of CSF1R-expressing cells recapitulates MG defects, confirming immune cell involvement.