FANCA facilitates G1/S cell cycle advancement, proliferation, migration and invasion in gastric cancer

• FANCA is overexpressed in gastric cancer cell lines and correlates with advanced pathologic stage and lymphatic metastasis. • Knockdown of FANCA suppresses proliferation, migration, invasion, and induces G1/S cell cycle arrest, while overexpression promotes these malignant behaviors. • In vivo xenograft experiments confirm that FANCA promotes gastric tumor progression. • FANCA exerts its oncogenic effects via the cell cycle pathway, suggesting it as a potential therapeutic target for gastric cancer.