Official PDF Translation•Stem Cell Research & Therapy

Extracellular vesicles from Yiguanjian-primed bone-marrow mesenchymal stem cells ameliorate chronic liver fibrosis via miR-7045-5p

Authors: Zhejun Liu; Xiaodan Jiang; Hongjie You; Zuoqing Tang; Yun Ma; Niancong Che; Chongyang Ma; Wenlan Liu

DOI: 10.1186/s13287-025-04780-xStatus: Verified Translated Edition

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Key Findings in This Report

• YGJ preconditioning enhances the anti-fibrotic cargo of BMSC-EVs, specifically upregulating miR-7045-5p. • YGJ-EVs deliver miR-7045-5p to hepatic stellate cells, inhibiting the Akt/AMPK/TFEB pathway and promoting lysosomal biogenesis and mitophagy. • In a CCl4-induced mouse model, YGJ-EVs ameliorate liver fibrosis and improve hepatic function, highlighting their therapeutic potential. • miR-7045-5p overexpression alone attenuates TGF-β1-induced HSC activation, confirming its causative role in the anti-fibrotic effect.