• S. aureus infection significantly impacts the migration, differentiation, and activity of mesenchymal stem cells (MSCs), which are crucial for regenerative medicine.
• Stem cell therapy, particularly using MSCs and hematopoietic stem cells, offers promising anti-inflammatory and immunomodulatory strategies against S. aureus-induced inflammatory disorders.
• Understanding the molecular mechanisms by which S. aureus affects stem cells can enhance the efficacy of stem cell-based treatments for infectious diseases.
• This review provides new insights into the therapeutic potential of adult stem cells in managing S. aureus infections, addressing the urgent need for alternatives to antibiotics.