Key Takeaways & Executive Findings
- •• Ferroptosis-related research in diabetes has grown substantially from 2015 to 2025, with 758 publications analyzed. • Key research hotspots include oxidative stress, cell death, and lipid peroxidation, with clusters on diabetic nephropathy, cardiomyopathy, and GPX4. • The regulatory network of ferroptosis is emerging as a novel therapeutic target for diabetes and its complications. • CiteSpace visualization revealed influential authors, institutions, and journals, highlighting Cell as a central knowledge hub.
Abstract
BACKGROUND: Oxidative stress induced by chronic hyperglycemia and impaired antioxidant systems are one of the core mechanisms underlying the onset and progression of diabetes mellitus. Ferroptosis, a new type of programmed cell death caused by iron-dependent lipid peroxidation, has received considerable academic interest due to its association with diabetes. OBJECTIVE: To reveal the current status and trends of ferroptosis-related research in the field of diabetes mellitus using bibliometric methods, aiming to offer academic resources to further develop this research area. METHODS: Based on the Web of Science Core Collection database, with a time span set from January 1, 2015 to January 1, 2025, 797 articles related to ferroptosis in the field of diabetes were retrieved. After deduplication, 758 high-quality articles were analyzed using CiteSpace (6.2.R1) for visualization of publication output, country/institution collaboration, high-impact authors/reference co-citation, keyword co-occurrence/clustering/burst detection, and international frontier trends. RESULTS AND CONCLUSION: Bibliometric analysis showed a substantial growth in ferroptosis-related research in diabetes. Among the 758 records, Linkermann, Andreas was the most prolific author, while Dixon SJ established an academic influence benchmark with 420 citations. The journal Cell served as a key knowledge dissemination hub. The most frequent keywords included oxidative stress, cell death, and lipid peroxidation, with clusters mainly focusing on diabetic nephropathy and cardiomyopathy, glutathione peroxidase 4, and necroptosis. The application of ferroptosis regulatory networks is deepening and has become an emerging paradigm for targeted therapy research in diabetes and its complications.
1. Introduction
Chronic hyperglycemia in diabetes mellitus leads to damage in organs such as the heart, kidneys, and retina, causing severe complications like diabetic nephropathy, cardiomyopathy, and retinopathy, which greatly impair patients' quality of life. The prevention and treatment situation is extremely severe, and effective therapeutic strategies are urgently needed.
Ferroptosis is a novel form of iron-dependent non-apoptotic programmed cell death, characterized by decreased cellular antioxidant capacity and accumulation of lipid reactive oxygen species, leading to oxidative cell death. Studies have shown that ferroptosis plays a role in diabetes and is a key factor in the pathogenesis of various endocrine diseases. Diabetes is characterized by chronic hyperglycemia, and glucose homeostasis is mainly regulated by insulin and glucagon. Research has confirmed that iron metabolism participates in multiple processes of glucose metabolism, such as insulin secretion, hepatic metabolism, and lipid metabolism, and maintains glucose homeostasis in multiple organs and tissues. Therefore, many scholars believe that ferroptosis may play a crucial role in the diagnosis, treatment, and prognosis of diabetes, making it a hot topic in the field.
Although ferroptosis is considered a potential therapeutic mechanism, its application in diabetes is rapidly evolving. To deeply explore the current status of ferroptosis mechanisms in diabetes, this study employed bibliometric methods for detailed statistical and quantitative analysis. This method uses mathematical and statistical tools to evaluate confirmed and emerging research trends, including co-authorship, co-citation, and keyword analysis. Through this bibliometric approach, the study analyzed the current status and development trends of ferroptosis-related research in diabetes.
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Chen Xianxian, Xu Chengfeng, Huang Wenyi, Yang Chenfan, Su Tongshan, Li Yu, Yan Yu, Li Chun (2026). Diabetes mellitus and ferroptosis: a visual analysis of related research literature. Chinese Journal of Tissue Engineering Research. https://doi.org/10.12307/2026.21558
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Frequently Asked Questions
What is the main objective of this study?
The main objective is to reveal the current status and trends of ferroptosis-related research in the field of diabetes mellitus using bibliometric methods, aiming to offer academic resources for further development in this area.
What database and time span were used for the literature search?
The study used the Web of Science Core Collection database, with a time span from January 1, 2015 to January 1, 2025.
How many articles were included in the analysis?
A total of 758 high-quality articles were included after deduplication from an initial retrieval of 797 articles.
What are the key research hotspots identified in this field?
Key hotspots include oxidative stress, cell death, and lipid peroxidation, with clusters focusing on diabetic nephropathy, cardiomyopathy, glutathione peroxidase 4, and necroptosis.
What is the significance of ferroptosis in diabetes research?
Ferroptosis is emerging as a novel therapeutic target for diabetes and its complications, as its regulatory network is being increasingly explored for targeted therapy.
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