• Portal vein infusion of BMSCs significantly ameliorates scald-induced hepatic lipid metabolism disorders in rats, improving body weight recovery and reducing hepatic lipid accumulation.
• Integrated transcriptomic and metabolomic analyses reveal that BMSC therapy modulates key pathways including NF-κB/Gadd45a signaling, sphingolipid metabolism, and hepatic lipid conversion.
• BMSC treatment normalizes serum lipid profiles and attenuates liver injury, suggesting a systemic therapeutic effect on metabolic disturbances post-scald.
• The study provides a theoretical foundation for clinical application of BMSCs in treating hepatic lipid metabolism disorders secondary to severe burn injury.