Official PDF Translation•Stem Cell Research & Therapy

Apoptotic vesicles derived from bone marrow mesenchymal stem cells increase angiogenesis in a hind limb ischemia model via the NAMPT/SIRT1/FOXO1 axis

Authors: Jinxing Chen; Zekun Shen; Bingyi Chen; Shuang Liu; Yifan Mei; Kai Li; Ziyang Peng; Chaoshuai Feng; Weiyi Wang; Shaoying Lu

DOI: 10.1186/s13287-025-04245-1Status: Verified Translated Edition

Sponsored AdvertisementAd Placement Area

reCAPTCHA Bot Shield Active

Preparing Secure Academic Download

Verifying human reader & generating high-resolution document...

Verifying Document Integrity15s remaining

← Back to Article

Protected by Google reCAPTCHA v3.•Privacy•Terms

Sponsored ContentAdSense In-Feed Ad Slot

Key Findings in This Report

• BMSC-derived apoptotic vesicles (ApoVs) significantly improve hindlimb ischemia by promoting angiogenesis. • ApoVs are internalized by HUVECs via dynamin-, clathrin-, and caveolin-mediated endocytosis. • Mechanistically, ApoVs transfer NAMPT to endothelial cells, activating the NAMPT/SIRT1/FOXO1 axis. • This study provides a novel cell-free therapeutic strategy for chronic limb-threatening ischemia (CLTI).