Official PDF Translation•Acta Biochimica et Biophysica Sinica

ANT1 suppression inhibits the progression of colorectal cancer by suppressing PINK1/Parkin-mediated mitophagy

Authors: Jin Ji; Mingrui Jiang; Shantanu Baral; Qiannan Sun; Dong Tang; Wei Wang; Jun Ren; Daorong Wang

DOI: 10.3724/abbs.2025154Status: Verified Translated Edition

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Key Findings in This Report

• ANT1 is overexpressed in colorectal cancer tissues and correlates with poor patient prognosis. • Knockdown of ANT1 suppresses CRC cell proliferation, migration, and invasion by inhibiting PINK1/Parkin-mediated mitophagy. • PINK1 overexpression partially rescues the cellular dysfunction caused by ANT1 knockdown, highlighting a potential therapeutic axis. • In vivo xenograft studies confirm that ANT1 knockdown significantly inhibits tumor growth, suggesting ANT1 as a promising therapeutic target for CRC.