Official PDF Translationā¢Stem Cell Research & Therapy
An Open Phase I/IIa Study Evaluating Safety, Patient-Reported Outcomes, and Voice Function After Surgery, Local Administration of Mesenchymal Stromal Cells, and Voice Training in Patients with Vocal Fold Scarring and Dysphonia
Authors: Erika Bergstrƶm Bƶrlin; Ulrika Nygren; Maria Sƶdersten; Svante Granqvist; Nadir Kadri; Ida Rasmusson Duprez; Katarina Le Blanc; Stellan HertegƄrd
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Key Findings in This Report
ā¢ Local injection of autologous bone marrow-derived MSCs combined with voice training was safe with no treatment-related side effects over 36 months.
ā¢ Patient-reported outcomes improved significantly, with Voice Handicap Index scores decreasing by a mean of 25.9 points at 12 months.
ā¢ Clinically relevant improvements were observed in 63ā88% of patients across various voice function parameters.
ā¢ All participants reported reduced vocal strain after voice training, suggesting potential added benefit of a structured post-operative protocol.
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