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Protected by Google reCAPTCHA v3.•Privacy•Terms Key Findings in This Report
• aFGF-overexpressing ADSCs significantly accelerate diabetic wound healing in a dose-dependent manner, with 3×10⁶ cells showing optimal efficacy.
• The treatment enhances angiogenesis (CD31), promotes M2 macrophage polarization (CD163), and reduces pro-inflammatory markers (CD86).
• Mechanistically, aFGF-ADSCs modulate inflammatory responses, accelerate epithelialization, and optimize collagen deposition.
• This gene-modified stem cell approach offers a promising new therapeutic strategy for chronic diabetic wounds.