Advancements in cell-based therapies for thermal burn wounds: a comprehensive systematic review of clinical trials outcomes

• Cell-based therapies, including keratinocytes, fibroblasts, and mesenchymal stem cells, show significant promise as alternative treatments for burn wounds, with 30 clinical trials involving 970 patients demonstrating positive outcomes. • The systematic review identified a predominance of cultured cell preparation methods (25 out of 30 trials) and a mix of allogeneic (17 trials) and autologous (13 trials) graft types, indicating diverse clinical applications. • Combined cell therapies, such as keratinocytes with fibroblasts or melanocytes, were commonly employed, suggesting that multi-cell approaches may enhance wound healing and regeneration. • The choice of cell-based treatment must be individualized based on patient condition and burn severity, as no single approach fits all cases, highlighting the need for personalized regenerative medicine strategies.