Official PDF Translation•Acta Biochimica et Biophysica Sinica

Acetyl-11-keto-β-boswellic acid restrains the progression of synovitis in osteoarthritis via the Nrf2/HO-1 pathway

Authors: Jing Zhou; Xueyan Li; Zeyu Han; Yinhua Qian; Lang Bai; Qibin Han; Maofeng Gao; Yi Xue; Dechun Geng; Xing Yang; Yuefeng Hao

DOI: 10.3724/abbs.2024102Status: Verified Translated Edition

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Key Findings in This Report

• AKBA suppresses LPS-induced FLS activation, reducing migration, invasion, inflammatory mediators, MMPs, and ROS production in vitro. • The therapeutic effects of AKBA are mediated through activation of the Nrf2/HO-1 signaling pathway, as confirmed by Nrf2 inhibitor ML385 reversal. • In a rat OA model (ACLT+DMM), AKBA alleviates synovial inflammation and fibrosis, highlighting its in vivo efficacy. • AKBA emerges as a promising therapeutic candidate for OA by targeting oxidative stress and synovitis via Nrf2/HO-1 axis.